Vol. 10 Suplement 2004

This issue contains abstracts of the lectures and research communications presented during the international conference:

W. MEJBAUM-KATZENELLENBOGEN'S MOLECULAR BIOLOGY SEMINARS, 11. AMPHIPHILES AND THEIR AGGREGATES IN BASIC AND APPLIED SCIENCE, MAY 15 - 19, 2005 , WROCŁAW/KLICZKOW, POLAND.

Its publication cost was covered by the conference organisers.

Conference was supported by:
University of Wrocław
Ministry of National Education and Sport
Pharmaceutical Research Institute
Polish Network of Cellular and Molecular Biology UNESCO/PAS
Academic Center of Biotechnology of Lipid Aggregates, University of Wrocław
Committee of Biochemistry and Biophysics Polish Academy of Sciences
Phospholipid GmbH
Malvern Instruments
Novasome Sp. z o.o.
PPH MARKER
with the help of:
Scientific Association of Biotechnology Students "Przybysz"
- University of Wroclaw
Biophysical Student Society "Micela"
- Technical University Wroclaw
Volume 6 (2001) pp 449-556
Abstracts of the invited lectures
Abstracts List PHARMACOKINETICS, BIODISTRIBUTION AND BIOAVAILABILITY OF LIPOSOMAL DRUGS
Theresa M. Allen, G. Charrois and K. Laginha - [Rozmiar: 1332 bajtów]p10

FROM NANOTECHNOLOGY TO NANOMEDICINE: OUR LIPOSOME EXPERIENCE
Yechezkel Barenholz - [Rozmiar: 1332 bajtów]p12

LIPID ORGANIZATION IN CISPLATIN NANOCAPSULES: LIPID-COATED AGGREGATES OF CISPLATIN WITH HIGH CYTOTOXICITY
Vladimir Chupin, A. I. P. M. De Kroon and B. De Kruijff - [Rozmiar: 1332 bajtów]p13

PEG-STABILIZED BILAYER DISKS: FUNDAMENTALS AND PHARMACEUTI-CAL/BIOTECHNICAL APPLICATIONS OF A NOVEL MODEL MEMBRANE
Katarina Edwards, Emma Johansson and Anna Lundquist - [Rozmiar: 1332 bajtów]p15

NMR STUDIES ON SINGLE LIPID BILAYERS SUPPORTED IN CYLINDRICAL ALUMINUM OXIDE NANOPORES - RECONSTITUTION OF GPCR
Holly C. Geade, Olivier Soubias, Keith M. Luckett, Ivan V. Polozov, Karen K.Y. Wong, Alexei A. Yeliseev and Klaus Gawrisch - [Rozmiar: 1332 bajtów]p17

MOLECULAR INTERACTIONS AND DYNAMICS IN LIPOSOME-DRUG SYSTEMS REVEALED BY EPR SPECTROSCOPY
Pál Gróf - [Rozmiar: 1332 bajtów]p19

ABOUT NON-BILAYER PHASES IN THE MECHANISM OF LIPOPLEX-MEDIATED GENE DELIVERY
Dick Hoekstra, Joanna Rejman, Fuxin Shi and Inge Zuhorn - [Rozmiar: 1332 bajtów]p21

DNA CONDENSATION CHARACTERISED BY FLUORESCENCE CORRELATION SPECTROSCOPY (FCS)
Martin Hof, Teresa Kral, Marek Langner, Noppadon Adjimatera and Ian S. Blagbrough - [Rozmiar: 1332 bajtów]p23

TARGETING LIPOSOMES TO THE ENDOTHELIUM
Jan A.A.M. Kamps, Martin Bartsch, Sigridur A. Asgeirsdottir, Henriette W.M. Morselt, Gerrit L. Scherphof and Grietje Molema - [Rozmiar: 1332 bajtów]p26

LIPOSOMES: WHAT CAN BE BETTER?
Alexander Kaplun - [Rozmiar: 1332 bajtów]p28

FLUCTUATING MEMBRANE PORES -A POSSIBLE MECHANISM FOR THE ACTION OF THE ANTIBIOTIC PEPTIDE KLA1
D. Kim, M. Dathe, S. Bezrukov, Th. Hauss, S. Dante and Beate KlĂśsgen - [Rozmiar: 1332 bajtów]p31

TARGETED MULTIMODAL LIPOSOMES FOR IMAGING AND RADIONUCLIDE THERAPY
Gerben A. Koning, Willem Mulder, Gustav J. Strijkers, Klaas Nicolay, Sander Zielhuis, Frank Nijsen, Marjan M. Fretz, Gert Storm and Gerard C. Krijger - [Rozmiar: 1332 bajtów]p32

MOLECULAR DYNAMICS SIMULATIONS OF LIPID PHASE TRANSFORMATIONS
Siewert-Jan Marrink - [Rozmiar: 1332 bajtów]p35

LIPOSOMES: FROM THE ORIGIN OF LIFE TO NANOTHERAPY
M. Reza Mozafari - [Rozmiar: 1332 bajtów]p36

LIPOSOMES IN INFECTIOUS DISEASES
Abdelwahab Omri - [Rozmiar: 1332 bajtów]p38

PEPTIDE-LIPID INTERACTIONS IN A BILAYER: MOLECULAR MODELLING STUDIES
Marta Pasenkiewicz-Gierula, Tomasz Róg and Krzysztof Murzyn - [Rozmiar: 1332 bajtów]p39

ROLE OF CLATHRIN- AND CAVEOLAE-MEDIATED ENDOCYTOSIS IN GENE TRANSFER MEDIATED BY LIPO- AND POLYPLEXES
Joanna Rejman and Massimo Conese - [Rozmiar: 1332 bajtów]p41

ORIENTATIONAL AND CONFORMATIONAL CHANGES IN TRANSMEMBRANE DOMAINS OF MEMBRANE PROTEINS
Jean-Marie Ruysschaert - [Rozmiar: 1332 bajtów]p42

MODELING BIOMINERALIZATION USING LIPID SURFACES
V. Matti J. Säily, Samppa J. Ryhänen, Arimatti Jutila, Mikko J. Parry and Paavo K. J. Kinnunen - [Rozmiar: 1332 bajtów]p43

INVOLVEMENT OF PLASMA PROTEINS IN LIPOSOME-HEPATOCYTE INTERACTIONS
Xuedong Yan, Gerrit L. Scherphof and Jan A.A.M. Kamps - [Rozmiar: 1332 bajtów]p44

CHOLESTEROL RICH DOMAINS ARE ESSENTIAL FOR INTERACTION OF LIPOSOMES WITH CELLS
Marjeta Šentjurc and Tilen Koklič - [Rozmiar: 1332 bajtów]p48

NANOPARTICLES FOR TARGETED DELIVERY OF ANTICANCER AGENTS
Gert Storm, Grietje Molema, Martin Woodle, Bart Metselaar and Raymond Schiffelers - [Rozmiar: 1332 bajtów]p51

LECITHIN - PHARMACEUTICAL APPLICATIONS EXPANDED BEYOND LIPOSOMES
Małgorzata Sznitowska - [Rozmiar: 1332 bajtów]p52

ATP-LOADED LIPOSOMES AND IMMUNOLIPOSOMES PROTECT ISCHEMIC MYOCARDIUM IN ISOLATED RAT HEARTS AND IN RABBITS WITH EXPERIMENTAL MYOCARDIAL INFARCTION
Vladimir P. Torchilin, D.D. Verma, T.S. Levchenko, W.C. Hartner and E.A. Bernstein - [Rozmiar: 1332 bajtów]p53

AMPHIPHILIC POLYMER AGGREGATES AND THEIR EXPLOITATION AS BIOAVAILABILITY ENHANCEMENT NANOMEDICINES
Ijeoma F. Uchegbu, Andreas G. Schatzlein, Woei Ping Cheng, Dennis Wong, Vitaliy Khutoryanskiy and Xiaozhong Qu - [Rozmiar: 1332 bajtów]p55

MICROSTRUCTURE OF DNA - LIPOSOME AGGREGATES IN PRESENCE OF METAL CATIONS
Daniela Uhríková, Mária Hanulová, Adrian Lengyel, Sérgio S. Funari and Pavol Balgavý - [Rozmiar: 1332 bajtów]p57

BIODEGRADABLE POLYMERIC MICELLES BASED ON THERMOSENSITIVE POLY((METHACRYLAMIDO)ALKYL OLIGOLACTATE) FOR DELAYED DRUG DELIVERY
Cornelus F. van Nostrum, Osamu Soga, Cristianne J.F. Rijcken, Aissa Ramzi, Theo F.J. Veldhuis and Wim E. Hennink - [Rozmiar: 1332 bajtów]p59

KINETICS AND THERMODYNAMICS OF THE INTERACTION OF AMPHIPHILES WITH SOFT LIPID INTERFACES
Winchil L. C. Vaz, M. J. Moreno, J. L. Sampaio, M. S. C. Abreu and L. M. B. B. Estronca - [Rozmiar: 1332 bajtów]p62

ORAL AND POSTER COMMUNICATIONS
List of Abstracts THE EFFECTS OF LIPOSOME COMPOSITION AND TEMPERATURE ON THE STABILITY OF LIPOSOMES AND THE INTERACTION OF THESE LIPOSOMES WITH HUMAN NEUTROPHILS
Omar Moh'd Atrouse - [Rozmiar: 1332 bajtów]p66

LIPOSOMAL IMATINIB: AN EPR AND DSC STUDY
Szabolcs Béni, Marianna Budai, Béla Noszál and Pál Gróf - [Rozmiar: 1332 bajtów]p67

ANTIOXIDATIVE ACTIVITY OF SOME N-OXIDES
Halina Kleszczyłska, Dorota Bonarska, Hanna Pruchnik, Krzysztof Bielecki, Jacek Łuczyłski, Zenon Trela and Janusz Sarapuk - [Rozmiar: 1332 bajtów]p68

IMPACT OF POLYLYSINE DENDRIMERS ON BIOLOGICAL MEMBRANES
Marta Jokiel, Barbara Klajnert and Maria Bryszewska - [Rozmiar: 1332 bajtów]p69

MOLECULAR INTERACTIONS IN LOMEFLOXACIN–LIPOSOME SYSTEMS
Marianna Budai, Réka Pallaghy, Zsófia Szabó, Andreas Zimmer and Pál Gróf - [Rozmiar: 1332 bajtów]p70

POLY-LACTIDE-CO-GLYCOLIDE MICROSPHERES AND NATURAL PHOSPHOLIPID LIPOSOMES IN THE CONTEXT OF VACCINOLOGY
Wagner Quintilio, Osvaldo A. Sant’Anna, Célia S. Takata, Antônio Carlos Lopes and Maria Helena Bueno Da Costa - [Rozmiar: 1332 bajtów]p71

THE INFLUENCE OF ALKYLRESORCINOLS ON PHOSPHOLIPASE A2 ACTIVITY
Dominika Czajkowska, Jacek Mika, Maria Stasiuk and Arkadiusz Kozubek - [Rozmiar: 1332 bajtów]p73

THE EFFECT OF SEMISYNTHETIC DERIVATIVES OF PHENOLIC LIPIDS ON ACTIVITY OF MEMBRANE ENZYMES
Dominika Czajkowska, Maria Stasiuk and Arkadiusz Kozubek - [Rozmiar: 1332 bajtów]p74

EFFECTS OF BIOACTIVE AMPHIPHILES ON MODEL CELL MEMBRANES
Magali Deleu, Michel Paquot and Tommy Nylander - [Rozmiar: 1332 bajtów]p75

HEMOLYTIC ACTIVITY OF NEW LINEAR SURFACTIN ANALOGS
Samuel Dufour, Magali Deleu, Bernard Wathelet, Philippe Thonart, Katherine Nott and Michel Paquot - [Rozmiar: 1332 bajtów]p76

COMPARISON OF IN VITRO ANTIBACTERIAL ACTIVITY OF MEROPENEM AND GENTAMICIN ENCAPSULATED IN LIPOSOMES
Zuzanna Drulis-Kawa, Jerzy Gubernator, Agata Dorotkiewicz-Jach, Włodzimierz Doroszkiewicz and Arkadiusz Kozubek - [Rozmiar: 1332 bajtów]p77

INTERACTION OF DENDRIMERS WITH MODEL LIPID MEMBRANES ASSESSED BY DSC AND RAMAN SPECTROSCOPY
Konstaninos Gardikis, Sophia Hatziantoniou, Kyriakos Viras, Matthias Wagner and Costas Demetzos - [Rozmiar: 1332 bajtów]p78

MATHEMATICAL OPTIMIZATION FOR LIPOSOMAL DOXORUBICIN IN TUMOR
Rafal Hrynyk and Marek Langner - [Rozmiar: 1332 bajtów]p79

NUCLISOME™ - A NOVEL STRATEGY FOR RADIONUCLIDE CANCER THERAPY
Ludger M. Ickenstein, Lars Gedda, Jörgen Carlsson, Stefan Sjöberg and Katarina Edwards - [Rozmiar: 1332 bajtów]p80

A NOVEL MODEL MEMBRANE: DEVELOPMENT AND OPTIMIZATION OF STABLE BILAYER DISKS
Emma Johansson, Anna Lundquist and Katarina Edwards - [Rozmiar: 1332 bajtów]p81

TARGETED DRUG DELIVERY FOR ANTHRACYCLINS USING PEPTIDOLIPOSOMAL CONSTRUCTS
Sami Kaukinen, Sari Kuosmanen, Heli Valtanen, Ying Zhu, Ilkka Simpura, Merja Haikola, Marja Tähtinen, Mikko Reinman, Oula Penate Medina and Kalevi Kairemo - [Rozmiar: 1332 bajtów]p82

AMPHIPHILIC POLY-N-VINYLPYRROLIDONES – PROMISING BASIS FOR NOVEL DRUG DELIVERY SYSTEMS
Michail Shtilman, Anastasia Goryachaya, Aristidis Tsatsakis, Vladimir P. Torchilin and Andrey Kuskov - [Rozmiar: 1332 bajtów]p83

LAMELLAR PHASE OF SHORT AMPHIPHILES: MOLECULAR DYNAMICS SIMULATIONS COMPARED TO SIMPLE MESOSCOPIC MODELS
Claire Loison, Friederike Schmid and Michel Mareschal - [Rozmiar: 1332 bajtów]p84

THE INFLUENCE OF COMPOUNDS OF TIN ON THE DYNAMIC PROPERTIES OF LIPOSOME MEMBRANES
Dariusz Man, Marian Podolak and Grzegorz Engel - [Rozmiar: 1332 bajtów]p85

DEVELOPMENT OF NEW CONTROLLED RELEASE FORMULATIONS FOR THE DELIVERY OF A CURCUMIN DERIVATIVE USING LIPOSOMES AND DENDRIMERS
Eleni Markatou, Sophia Hatziantoniou ,Panagiotis Pantazis and Costas Demetzos - [Rozmiar: 1332 bajtów]p86

DEVELOPMENT OF A LIPOSOMAL FORMULATION OF A CYTOTOXIC LABDANE TYPE DITERPENE AND in vitro EVALUATION
Christina Matsingou, Kostas Dimas and Costas Demetzos - [Rozmiar: 1332 bajtów]p87

PROPERTIES OF DOTAP-CONTAINING LIPOSOMES – FLUORESCENCE STUDIES
Agnieszka Olżyńska, Piotr Jurkiewicz, Marek Langner and Martin Hof - [Rozmiar: 1332 bajtów]p88

INFLUENCE OF LIPOSOME SURFACE PROPERTIES ON LIPOSOME-ERYTHROCYTES INTERACTIONS
Grzegorz Paździor, Kinga Poleszczuk and Marek Langner - [Rozmiar: 1332 bajtów]p89

EFFECT OF ETHANOL ON LIPID BILAYER RELAXATION KINETICS
Magdalena Przybyło, Tomasz Borowik, Sebastian Kraszewski and Marek Langner - [Rozmiar: 1332 bajtów]p90

IN VIVO IMAGING USING LIPOSOMAL PHAGE DISPLAY PEPTIDE DERIVATES TARGETING INTEGRINS IN ACTIVATED LEUKOCYTES
Tanja-Maria Ranta, Heli Valtanen, Sami Kaukinen, Otto C. Boerman, Ilkka Simpura, Ying Zhu, Oula Penate Medina, Wim J.G. Oyen and Kalevi Kairemo - [Rozmiar: 1332 bajtów]p91

MOLECULAR DYNAMICS SIMULATION OF GLYCOLIPIDS BILAYER
Tomasz Róg, Ilpo Vattulainen and Mikko Karttunen - [Rozmiar: 1332 bajtów]p92

ISOTHERMAL TITRATION CALORIMETRY STUDIES OF SOLUBILIZATIN OF DPPC VESICLES BY AMPHIPHILIC QUATERNARY AMMONIUM SALTS
Hanna Pruchnik and Bożenna Różycka - Roszak - [Rozmiar: 1332 bajtów]p93

INCREASING SURFACE CHARGE DENSITY INDUCES INTERDIGITATION IN VESICLES OF CATIONIC AMPHIPHILE AND PHOSPHATIDYLCHOLINE
Samppa J. Ryhänen, Juha-Matti I. Alakoskela and Paavo K. J. Kinnunen - [Rozmiar: 1332 bajtów]p94

HOW DOES ISOPRENE PROTECT PLANT MEMEBRANES FROM THERMAL SHOCK?
Magdalena E. Siwko, Siewert-Jan Marrink and Alan E. Mark - [Rozmiar: 1332 bajtów]p95

RESORCINOLIC LIPIDS - DISTURB OR STABILIZE BIOLOGICAL MEMBRANES? MOLECULAR DYNAMICS SIMULATIONS
Magdalena E. Siwko, Siewert-Jan Marrink, Arkadiusz Kozubek and Alan E. Mark - [Rozmiar: 1332 bajtów]p96

CERAMIDE GENERATED IN THE OUTER LEAFLET OF THE PLASMA MEMBRANE CONTROLS SIGNALING OF FCIIA IMMUNORECEPTOR
Abo Bakr Abdel Shakor, Katarzyna Kwiatkowska, Agnieszka Strzelecka-Kiliszek and Andrzej Sobota - [Rozmiar: 1332 bajtów]p97

EVALAUTION OF IMMUNE RESPONSE AGAINST LEISHMANIASIS IN RESISTANCE C57 BL/6 MICE IMMUNIZED WITH LIPOSOMES CONTAINING AUTOCLAVED Leishmania major WITH BCG
Yahya Sohrabi, Mahmoud Reza Jaafari, Akram Miramin Mohammadi, Seyed Ebrahim Eskandari and Ali Khamesipour - [Rozmiar: 1332 bajtów]p98

THE EFFECT OF ALKYLRESORCINOLS ON BILAYER PHASE TRANSITION
Maria Stasiuk, Michał Kużdżał, Andrzej Hendrich and Arkadiusz Kozubek - [Rozmiar: 1332 bajtów]p99

THE EFFECT OF PS CONTENT ON THE ABILITY OF NATURAL MEMBRANES TO FUSE WITH POSITIVELY CHARGED LIPOSOMES AND LIPOPLEXES
Katarzyna Stebelska, Patrycja M. Dubielecka and Aleksander F. Sikorski - [Rozmiar: 1332 bajtów]p100

EXPLORING THE EFFECT OF ANAESTHETIC GASES ON BIOMEMBRANES
Lorna M. Stimson, Ilpo Vattulainen, Tomasz Róg and Mikko Karttunen - [Rozmiar: 1332 bajtów]p101

BIOLOGICAL EFFECTS OF LIPOSOMAL FORMULATION OF DIMIQ, POTENTIAL ANTITUMOR INDOLO[2,3-B]QUINOLINE AGENT ON HEPATOMA MORRIS 5123 CELLS
Katarzyna Suchoszek-Łukaniuk, Anna Jaromin, Wanda Peczyńska-Czoch, Łukasz Kaczmarek, Maria Malicka-Błaszkiewicz and Arkadiusz Kozubek - [Rozmiar: 1332 bajtów]p102

RECENT APPLICATIONS OF SOLVENT RELAXATION IN BIOMEMBRANES: EFFECT OF MEMBRANE CURVATURE AND BINDING OF ANTIBACTERIAL PEPTIDES
Jan Sýkora Jana Humpolíčková, Tanya Sheynis, Raz Jelinek and Martin Hof - [Rozmiar: 1332 bajtów]p103

THE APPLICATION OF THE STOCHASTIC MODEL OF CORRELATED CLUSTERS FOR ANALYSIS OF EXPERIMENTAL RESULTS
Bozena Szabat and Piotr Jurkiewicz - [Rozmiar: 1332 bajtów]p104

SUPERCRITICAL CARBON DIOXIDE IN THE BIOTECHNOLOGY OF AMPHIPHILES
José Da Cruz Francisco and Estera Szwajcer Dey - [Rozmiar: 1332 bajtów]p105

GMP-PRODUCTION OF LIPOSOMES - A NEW INDUSTRIAL APROACH
Andreas Wagner, Karola Vorauer-Uhl and Hermann Katinger - [Rozmiar: 1332 bajtów]p106

MELITTIN-LIPOSOME INTERACTIONS: DIRECT VISUALIZATION OF PEPTIDE INDUCED STRUCTURAL PERTURBATION
Per Wessman and Katarina Edwards - [Rozmiar: 1332 bajtów]p108

MICELLIZATION STUDIES OF N-ALKOXYCARBONYLMETHYL N-ALKYL-PIPERIDINIUM CHLORIDES BY ISOTHERMAL TITRATION CALORIMETRY
Edyta Woźniak, Anna Mozrzymas, Bożenna Różycka-Roszak and Zofia Dega-Szafran - [Rozmiar: 1332 bajtów]p109

LIPID CARRIERS FOR GENETIC DRUGS IN GENE THERAPY OF ACUTE LEUKEMIAS
Paulina Wyrozumska, Katarzyna Stebelska and Aleksander F. Sikorski - [Rozmiar: 1332 bajtów]p110

VESICLES FORMED IN PORES
Zygmunt H. Zawada - [Rozmiar: 1332 bajtów]p111

BINDING EFFECT OF PHENYLTIN AND PHENYLLEAD COMPOUNDS AND ITS MIXTURE WITH QUERCETIN TO THE LIPID BILAYER: IR AND 1HNMR STUDY
Romuald Żyłka, Janina Gabrielska and Stanisław Przestalski - [Rozmiar: 1332 bajtów]p112